Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 1

Research Article

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

Figure 1

VK2 inhibits cell proliferation in androgen-dependent and androgen-independent prostate cancer cell lines. VK2 inhibits cell proliferation of LNCaP, 22RV1, and DU145 with an IC50 of about 100 μM. Results showed that VK2 inhibited proliferation of both androgen-dependent (LNCaP) and androgen independent derived prostate cancer cells (22Rv1 and DU145) in a time- and dose-dependent manner. Nonmalignant prostate epithelial cells (RWPE-1) (Figure 1(d)) were not affected by VK2 treatment. Data presented here is representative of one of three similar experiments.

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