Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 5

Research Article

Vitamin K2, a Naturally Occurring Menaquinone, Exerts Therapeutic Effects on Both Hormone-Dependent and Hormone-Independent Prostate Cancer Cells

Figure 5

VK2 induced caspase-3 and caspase-8 activity in prostate cancer cells. Detection of caspase-3 and caspase-8 activity in LNCaP, 22RV1 and DU145 prostate cancer cells was measured using a commercially available colorimetric assay kit. Cells were treated with 100 μM of VK2 for 48 hrs. The samples were then analyzed for caspase-3 (Figure 5(a)) and caspase-8 (Figure 5(b)) activity. The results showed that VK2 treatment induced significant activation of caspase-3 and caspase-8 in LNCaP, 22RV1, and DU-145 prostate cancer cells ( ) compared to control treated (0.1% DMSO) prostate cancer cells. This data is representative of one of the three similar experiments.

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