Research Article
Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses
Table 4
Minimal inhibitory concentration of extracts, fractions, and subfractions of P. amboinicus against MRSA clinical isolates and ATCC.
| | Strain | Controls | Extracts
| Fractions | Subfractions | Van
(mg/mL) | DMSO
(μg/mL) | Bact
(% v/v) | EH
(mg/mL) | ET
(mg/mL) | F1 | F2 | F3 | F4 | F5 | F4a | F4b | F4c | F4d | F4e | F4f | F4g |
| | ATCC 25923 | 1 | no | + | 4 | 8 | no | no | no | 0.5 | no | 2 | 0.5 | 0.5 | 0.5 | no | no | no | | ATCC 65398 | 1 | no | + | 4 | 4 | no | no | no | 0.5 | no | 1 | 0.5 | 0.5 | 0.5 | no | no | no | | MRSA 01 | 2 | no | + | 4 | 8 | no | no | no | 0.5 | no | 1 | 0.5 | 0.5 | 0.5 | no | no | no | | MRSA 02 | 2 | no | + | 2 | 4 | no | no | no | 0.5 | no | 2 | 0.5 | 0.5 | 0.5 | no | no | no | | MRSA 03 | 1 | no | + | 2 | 8 | no | no | no | 0.25 | no | 1 | 0.5 | 0.5 | 0.5 | no | no | no | | MRSA 04 | 1 | no | + | 2 | 8 | no | no | no | 0.5 | no | | | | MRSA 05 | 1 | no | + | 4 | 4 | no | no | no | 0.5 | no | | | | MRSA 06 | 2 | no | + | 4 | 8 | no | no | no | 0.25 | no | | | | MRSA 07 | 2 | no | + | 2 | 8 | no | no | no | 0.5 | no | | | | MRSA 08 | 1 | no | + | 2 | 4 | no | no | no | 0.5 | no | | | | MRSA 09 | 2 | no | + | 2 | 8 | no | no | no | 0.5 | no | | | | MRSA 10 | 1 | no | + | 2 | 4 | no | no | no | 0.5 | no | | | | MRSA 11 | 2 | no | + | 2 | 8 | no | no | no | 0.5 | no | | | | MRSA 12 | 2 | no | + | 2 | 8 | no | no | no | 0.5 | no | | | | MRSA 13 | 2 | no | + | 2 | 8 | no | no | no | 0.25 | no | | | | MRSA 14 | 2 | no | + | 2 | 8 | no | no | no | 0.5 | no | | |
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Bact: bacteria; CT: growth control; EH: hydroalcoholic extract; ET: ethanolic extract; F1: hexane fraction; F2: petroleum ether fraction; F3: dichloromethane fraction; F4: ethyl acetate fraction; F5: methanol fraction; F4a–g: subfractions of fraction F4; Van: vancomycin; DMSO: dimethyl sulfoxide; no: no activity.
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