Evidence-Based Complementary and Alternative Medicine

Research Article

Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses

Table 5

FIC values (FIC) and FIC index (IFIC) of hydroalcoholic extract (a) and the fraction F4 (b) in combination with vancomycin (Van) or ciprofloxacin (Cip) against a standard strain of S. aureus (ATCC 65398) and three randomly chosen MRSA strains. The interaction between the drugs and the plant was additive (A), synergic, (S) or indifferent (I).

(a) Hydroalcoholic extract (EH)


	CIF		ICIF	Interaction	CIF		IFIC	Interaction
	Eh	Van	ICIF	Interaction	Eh	Cip	IFIC	Interaction

ATCC (65398)	1	1	2	I	0.5	2	2.5	I
MRSA 05	1	2	3	I	0.5	2	2.5	I
MRSA 08	1	1	2	I	0.5	2	2.5	I
MRSA 12	1	1	2	I	0.5	2	2.5	I

(b) Ethyl acetate fraction (F4)


	CIF		ICIF	Interaction	CIF		IFIC	Interaction
	F4	Van	ICIF	Interaction	F4	Cip	IFIC	Interaction

ATCC (65398)	0.5	0.25	0.75	S	0.5	0.5	1	A
MRSA 05	0.5	0.25	0.75	S	0.5	0.5	1	A
MRSA 08	0.5	0.25	0.75	S	0.5	0.5	1	A
MRSA 12	0.5	0.25	0.75	S	0.5	0.5	1	A

CIF: fractional inhibitory concentration; ICIF: fractional inhibitory concentration index.