Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses

Table 6

Mice infected subcutaneously with an MRSA clinical isolate (strain #08) and treated intra-peritoneally with hydroalcoholic extract (HE) or fraction F4 from P.  amboinicus or with vancomycin. The results were expressed by bacterial growth (log colony-forming unities (CFU) per site), abscess volume mean (mm³), and by indices of the histopathological analysis.

Treatment	Dosage; (mg/kg)	MIC; (mg/mL)	Abscess volume mean; (mm^3  ± SD)	𝑃	Bacterial cell count; Log CFU/site; (𝑥  ± SD)	𝑃	Histopathological analysis; (index sum ± SD)	𝑃
Control			130.0±29.1		7.2±0.41		11.4±0.78
HE	500	2.0	63.0±26.7	<0.01	5.6±0.51	<0.01	6.7±2.9	<0.01
	250		99; 99.5±37.3	N.S.	6.9±0.48	<0.05	9.3±0.82	N.S.
F4	500	0.5	26.9±14.5	<0.001	4.7±0.89	<0.001	5.4±3.1	<0.001
	250		55.1±11.8	<0.001	5.3±0.48	<0.001	6.7±2.7	<0.01
Vancomycin	20	0.2	46.0±22.9	<0.001	4.2±0.91	<0.01	7.5±1.6	<0.01
	10		82.7±27.9	<0.05	5.4±0.86	<0.05	7.8±2.3	<0.05

MIC: minimal inhibitory concentration; SD: standard deviation, N.S.: not significant.