Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 6

Research Article

Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses

Table 6

Mice infected subcutaneously with an MRSA clinical isolate (strain #08) and treated intra-peritoneally with hydroalcoholic extract (HE) or fraction F4 from P.  amboinicus or with vancomycin. The results were expressed by bacterial growth (log colony-forming unities (CFU) per site), abscess volume mean (mm3), and by indices of the histopathological analysis.

TreatmentDosage
(mg/kg)
MIC
(mg/mL)
Abscess volume mean
(mm3  ± SD)
Bacterial cell count
Log CFU/site
(   ± SD)
Histopathological analysis
(index sum ± SD)

Control
HE5002.0 <0.01 <0.01 <0.01
25099
N.S. <0.05 N.S.
F45000.5 <0.001 <0.001 <0.001
250 <0.001 <0.001 <0.01
Vancomycin200.2 <0.001 <0.01 <0.01
10 <0.05 <0.05 <0.05

MIC: minimal inhibitory concentration; SD: standard deviation, N.S.: not significant.