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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 294789, 6 pages
http://dx.doi.org/10.1155/2013/294789
Research Article

Electroacupuncture Stimulation at CV12 Inhibits Gastric Motility via TRPV1 Receptor

1Key Laboratory of Integrated Acupuncture and Drugs Constructed by the Ministry of Education and Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210029, China
2Toho University, Tokyo 143-8540, Japan
3Nanjing Medical University, Nanjing 210029, China

Received 25 February 2013; Accepted 9 August 2013

Academic Editor: Jian Kong

Copyright © 2013 Zhi Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric dysmotility is one of the major pathophysiological factors in functional gastrointestinal disorders. Acupuncture, as one of the alternative approaches, is efficacious in the treatment of gastrointestinal motility disorders; however, the mechanism underlying its action is unclear. In the present study, we used both capsazepine, a TRPV1 antagonist, and TRPV1 knockout mice. Animals were divided into wild-type group (WT), capsazepine injection group (CZP, 0.5 mg/kg, i.p.), and TRPV1 knockout mice group (TRPV1−/−). Each of these three groups was divided into three subgroups, which were subjected to EA stimulation at acupoint Zhongwan (CV12) at a different intensity (1, 2, or 4 mA). We demonstrated that electroacupuncture at Zhongwan (CV12) markedly inhibited gastric motility at 2 and 4 mA in an intensity-dependent manner in wild-type mice. The inhibitory effect was also observed in capsazepine-injected and TRPV1−/− mice but was no longer intensity dependent, indicating that TRPV1 is partially involved in the electroacupuncture-mediated modulation of gastric motility.