Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism

Table 1

Effect of antcin C on AAPH-induced hepatic enzyme leakage, lipid peroxidation, and glutathione depletion in human hepatic HepG2 cells.

Parameters		AAPH (10 mM)
			Antcin C (𝜇M)			Silymarin (𝜇M)
	Control	2.5	5	10	100
ALT (U/L)	1.3±0.5	3.2±1.9^†	2.5±0.6^∗	2.0±0.1^∗∗	1.4±0.1^∗∗∗	0.1±0.2^∗∗∗
AST (U/L)	3.4±0.1	4.8±0.1^†	4.5±0.5^∗	4.1±0.5^∗∗	3.5±0.1^∗∗∗	2.4±0.2^∗∗∗
GSH (mM)	50.5±5.3	21.7±4.2^†	50.4±4.5^∗	88.4±4.8^∗∗	111.5±3.7^∗∗∗	123.7±1.0^∗∗∗
MDA (mM)	1.2±0.2	3.5±0.3^†	2.7±0.2^∗	2.1±0.3^∗∗	1.5±0.2^∗∗∗	1.4±0.2^∗∗∗

Values represent the mean ± SD of three independent experiments. ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 was considered significant for sample versus. AAPH. ^†𝑃<0.05 was considered significant for control versus AAPH.