Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism

Table 5

Correlation between CYP1A2 genotypes and FZHY efficacy on Child-Pugh scores in HBC.

Genotypes	Effective (%) 𝑛=25	Invalid (%) 𝑛=86	𝑃^#	OR	95% CI
CYP1A2-5347
CC	17 (70.80)	63 (75.00)
CT	6 (25.00)	20 (23.80)	0.844	0.899	0.312, 2.591
TT	1 (4.20)	1 (1.20)	0.393	0.270	0.016, 4.541
CT + TT	7 (29.20)	21 (25.00)	0.681	0.810	0.295, 2.221
CYP1A2-2964
GG	10 (41.70)	46 (53.50)
GA	11 (45.80)	30 (34.90)	0.289	0.593	0.224, 1.567
AA	3 (12.50)	10 (11.60)	0.700	0.725	0.168, 3.121
GA + AA	14 (58.30)	40 (46.50)	0.306	0.621	0.249, 1.552
CYP1A2-733
CC	3 (12.50)	9 (10.50)
CA	9 (37.50)	38 (44.20)	0.653	1.407	0.316, 6.277
AA	12 (50.00)	39 (45.30)	0.914	1.083	0.252, 4.656
CA + AA	21 (87.50)	77 (89.50)	0.777	1.222	0.304, 4.921

The bold font emphasizes the result was statistically significant (𝑃<0.05)