High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects
Figure 4
Pathological features for effects of the YGJ herbal therapy on DMN-induced liver fibrosis. ((a), (b), and (c)) The normal lateral left liver architecture with central veins and radiating hepatic cords was observed in normal control rats. ((d), (e), and (f)) Fatty degeneration, necrosis, infiltration of inflammatory cells, and apparent formation of fibrotic septa were present in the 2-week DMN-treated group. ((g), (h), and (i)) The more severer fibrotic liver architecture images were present in the 4-week DMN-treated group. ((j), (k), and (l)) The degree of liver fibrosis was significantly reduced in the YGJ-treated group. ((a), (d), (g), and (j)) Lateral left liver architectures of HFU (40 MHz) images. ((b), (e), (h), and (k)) Tissues stained with H&E, bar = 2.0 mm. ((c), (f), (i), and (l)) Tissues stained with Masson’s trichrome, bar = 2.0 mm.
