Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet

Figure 1

Representative images of H&E stain in livers from RCD- or HFD-fed hamsters receiving 8-week treatment. Photomicrographs are of tissues isolated from vehicle-treated RCD-fed hamsters (a), vehicle-treated HFD-fed hamsters (b), zerumbone-treated HFD-fed hamsters (300 mg kg⁻¹ per day) (c), or lipanthyl-treated HFD-fed hamsters (100 mg kg⁻¹ per day) (d). Photomicrographs were taken at a magnification of 200x. The quantification of the hepatic lipid droplets accumulation was presented as the percentage of the blank area (lipid droplets) relative to the whole area of the photomicrograph (e). Values (mean ± SD) were obtained from each group of 5 animals in each group. ^b𝑃<.01 compared to the values of vehicle-treated RCD-fed hamsters. ^c𝑃<.05 and ^d𝑃<.01 compared to the values of vehicle-treated HFD-fed hamsters in each group, respectively.