Managing the Combination of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome with Chinese Herbal Extracts in High-Fat-Diet Fed Rats
Table 1
Summary of metabolic parameters in chow and HFD fed rats with variety of treatments.
Chow
HFD-Con.
HFD-RSG
HFD-SGE
Initial body weight, g
372 ± 16
414 ± 14†
409 ± 20
417 ± 16
Final body weight, g
412 ± 22
468 ± 19†
483 ± 32
438 ± 27*
Visceral fat mass, g
7.8 ± 1.2
14.60 ± 1.20‡
17.0 ± 1.4
8.9 ± 1.0**
Liver wt, g
11.7 ± 0.2
12.50 ± 0.90
13.3 ± 0.6
11.8 ± 0.6
Serum glucose, mM
6.75 ± 0.14
8.87 ± 0.24‡
7.65 ± 0.14*
8.15 ± 0.18
Serum insulin, mU
26.60 ± 0.22
46.25 ± 0.35‡
24.01 ± 0.18**
27.03 ± 0.31**
HOMA-IR
7.98 ± 0.09
18.23 ± 0.28‡
8.16 ± 0.17**
9.76 ± 0.29**
Serum TC, mM
3.98 ± 0.21
5.67 ± 0.24†
5.13 ± 0.32
4.35 ± 0.18*
Serum TG, mM
0.41 ± 0.03
1.03 ± 0.06†
0.59 ± 0.03*
0.51 ± 0.02**
Serum HDL-C, mM
1.20 ± 0. 22
0.86 ± 0.13‡
0.90 ± 0.16
0.96 ± 0.15
Serum LDL-C, mM
2.59 ± 0.52
4.34 ± 0.59‡
3.96 ± 0.67
3.16 ± 0.56*
Serum NEFA, mM
0.50 ± 0.10
0.77 ± 0.21†
0.57 ± 0.12*
0.58 ± 0.12*
Data are means ± SEM; rats/group. †, ‡ versus chow control; * and ** compared with HFD-Con. HOMA is defined as (fasting insulin × fasting glucose)/22.5. Visceral fat included epididymal fat pad and inguinal fat. TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; NFFA: nonfree fatty acids.
