Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia
Figure 1
Primary inflammation-induced mechanical and thermal hyperalgesia through carrageenan or CFA injection. (a) Electronic von Frey filament test; (b) radial heat assay; (c) and (d) the latency time for forepaw licking and jumping responses after exposure to a hot plate maintained at 50°C. (c) Latency to first forepaw licking, (d) escape times (jumping) within 5 minutes; (e) and (f) the hind paw withdrawal and rearing on exposure to a cold plate kept at 4°C; (e) withdrawal times; (f) rearing times within 5 minutes. Con: saline, Car: carrageenan and CFA: intraplantar injection into hind paw; Car-EA and CFA-EA: after carrageenan or CFA injection, needles inserted at the ST36 acupoint with electrical stimulation at 2 Hz. *, as compared to that of the baseline. **, as compared to that of the baseline. #; comparison between inflammation and EA-ST36 groups. ##; comparison between inflammation and EA-ST36 groups. CFA: complete Freund’s adjuvant. Solid lines mean carrageenan-injected group. Dot lines mean CFA-injected group.
