Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions
Figure 3
The schedule of animal trials and the effect of tanshinone I on airway hyperresponsiveness (AHR) parameters of pulmonary function. (a) The experimental designation for evidence-based lung tumorigenesis attenuation in animal trial. T1 was injected intraperitoneally (i.p.) at 1 mg/kg b.w. three times a week. Mice were sacrificed at 10 months of age after T1 administration for 4 months. (b) The Penh (enhanced pause) is a dimensionless value that represents a function of the proportion of maximal expiratory to maximal inspiratory box pressure signals and of the timing of expiration. Data were presented as mean ± SEM (). The AHR was measured at 6, 7, and 8 months. WT: wild-type FVB mice; Tg/Placebo: hVEGF- transgenic mice without T1 supplement; Tg/CM/Placebo: condition medium-treated transgenic mice without T1 supplement; Tg/CM/T1: condition medium treated transgenic mice with T1 supplement; NS: normal saline; MCh: methacholine.
