Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions

Figure 4

Photographs of whole lungs (a) and stained histopathologic slides of lung tissues (b) from wild-type-FVB mice, hVEGF-A₁₆₅^+/+ transgenic mice (Tg/Placebo), condition medium-treated transgenic mice (Tg/CM/Placebo), and condition medium treated transgenic mice with T1 supplement (Tg/CM/T1) groups. Tissues from the Tg/CM/T1 group were taken from 10-month-old hVEGF-A₁₆₅ overexpressing transgenic mice after T1 administration for 4 months. The tissue sections were stained with H&E and photographed at 200x magnifications. Scale bar = 5 mm.

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