Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions

Table 1

Lung tumorigenesis frequency of wild type, Tg/Placebo, Tg/CM/Placebo, and Tg/CM/T1 groups in the mouse lung tissues (n = 6) using histopathological image analysis.

Variable	Wild type	Tg/Placebo	Tg/CM/Placebo	Tg/CM/T1
Normal	100 (100%)	0 (0%)	0 (0%)	2 (33.3%)
Cyst	0 (0%)	2 (33.3%)	0 (0%)	3 (50%)
Damaged alveoli	0 (0%)	3 (50%)	4 (66.7%)	3 (50%)
Mild emphysematous change	0 (0%)	2 (33.3%)	0 (0%)	3 (50%)
Prominent emphysematous change	0 (0%)	3 (50%)	3 (50%)	1 (16.7%)
Hemosiderin-laden macrophages in alveoli	0 (0%)	3 (50%)	5 (83.3%)	1 (16.7%)
Old hemorrhage	0 (0%)	1 (16.7%)	2 (33.3%)	1 (16.7%)
Moderate lymphocytic infiltration	0 (0%)	2 (33.3%)	4 (66.7%)	1 (16.7%)
Marked chronic lymphoid infiltration	0 (0%)	2 (33.3%)	4 (66.7%)	1 (16.7%)
Neoplasm	0 (0%)	1 (16.7%)	1 (16.7%)	0 (0%)
Lymphoma	0 (0%)	1 (16.7%)	1 (16.7%)	0 (0%)
Adenocarcinoma	0 (0%)	3 (50%)	5 (83.3%)	1 (16.7%)