Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 8

Research Article

Molecular Mechanisms of Large-Conductance Ca2+-Activated Potassium Channel Activation by Ginseng Gintonin

Figure 8

A comparative drawing of the action modes between gintonin and ginsenoside Rg3 in BKCa channel activation. Gintonin activates BKCa channels via G protein-coupled LPA1 receptors. Gintonin-mediated BKCa channel activations are mediated by Ca2+ binding to the Ca2+ bowl, RCK, or via activations of Ca2+-dependent kinases, whereas ginsenoside Rg3 activates BKCa channels through direct interaction with a specific amino acid located at the pore entryway of channel proteins following depolarization but not receptor activation [24].

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