The Ethanol Extract of Zingiber zerumbet Attenuates Streptozotocin-Induced Diabetic Nephropathy in Rats

Table 1

Effects of different treatments on body weight, fasting blood glucose, and HbA_1c levels in rats.

Groups	Week 4	Week 8
Body weight (g rat^−1)
Normal + vehicle	291.13 ± 14.13^d	341.64 ± 13.48^d
STZ + vehicle	183.98 ± 13.14^b	221.28 ± 15.93^b
STZ + EEZZR 200	216.73 ± 12.26^b,c	242.62 ± 14.27^b,c
STZ + EEZZR 300	254.32 ± 15.09^a,c	282.71 ± 16.45^a,c
STZ + Met	276.85 ± 11.23^d	318.23 ± 13.21^d
Plasma glucose (mg dL^−1)
Normal + vehicle	93.42 ± 6.13^d	95.62 ± 7.83^d
STZ + vehicle	383.12 ± 15.26^b	401.53 ± 17.92^b
STZ + EEZZR 200	332.29 ± 14.16^b,c	317.07 ± 15.36^b,c
STZ + EEZZR 300	314.56 ± 16.29^b,c	289.42 ± 16.58^b,c
STZ + Met	273.46 ± 13.78^b,d	237.39 ± 14.26^b,d
HbAlc (%)
Normal + vehicle	4.81 ± 1.03^d	4.87 ± 1.21^d
STZ + vehicle	13.09 ± 2.67^b	13.62 ± 3.26^b
STZ + EEZZR 200	11.63 ± 1.75^b	11.21 ± 1.74^b
STZ + EEZZR 300	11.12 ± 3.07^b	10.41 ± 2.92^b
STZ + Met	9.96 ± 2.23^b	8.93 ± 2.17^b

STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 100 mg kg⁻¹ per day metformin (STZ + Met), 200 mg kg⁻¹ per day EEZZR (STZ + EEZZR 200), or 300 mg kg⁻¹ EEZZR (STZ + EEZZR 300). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to dissolve the test medications. Values (mean ± SD) were obtained for each group of 8 animals. aP < .05 and bP < .01 compared to the values of vehicle-treated normal rats (normal + vehicle). cP < .05 and dP < .01 compared to the values of vehicle-treated STZ-diabetic rats (STZ + vehicle), respectively.