Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings

Figure 3

Inhibitory effect of EOK (0.3 mg/mL) on the contraction induced by extracellular Ca²⁺ addition (0.3–10 mM) in rat aortic rings precontracted with phenylephrine (PE, 1 μM) (a) or KCl (60 mM) (b) in Ca²⁺-free Krebs-Henseleit solution and vasorelaxant responses induced by EOK (0.01–0.8 mg/mL) in rat aortic rings precontracted with PE (1 μM) in the presence or absence of nifedipine (10 μM). Values are expressed as mean ± SEM (𝑛=4). *𝑃<0.05 versus control. ^#𝑃<0.05 and ^##𝑃<0.01 versus absence of nifedipine group.

(a)

(b)

(c)