Effect of Bee Venom Acupuncture on Oxaliplatin-Induced Cold Allodynia in Rats
Figure 4
Effects of opioid and adrenergic receptor antagonists on BVA-induced anti-allodynic action. The behavioral tests for cold allodynia were performed before pretreatment of antagonists and after BVA (0.25 mg/kg) treatment at GV3 acupoint. (a) N/S + BV (normal saline (i.p.) pretreatment + BVA, ). (b) Naloxone + BV (naloxone (2 mg/kg, i.p.) pretreatment + BVA, ). (c) Phentolamine + BV (phentolamine (2 mg/kg, i.p.) pretreatment + BVA, ). In N/S + BV and Naloxone + BV groups, TWLs after BVA significantly increased as compared with baseline TWL. In contrast, Phentolamine + BV group showed no significant increase in TWL after BVA. Note that TWL of three subjects of Phentolamine + BV group substantially increased after BVA, whereas TWL of the other three subjects did not. (d) N/S i.t. + BV (normal saline (i.t.) pretreatment + BVA, ). (e) Idazoxan i.t. + BV (idazoxan pretreatment (50 μg, i.t.) + BVA, ). Data are presented as mean ± SEM. Dots and lines represent the TWL change of individual subject. , by paired t-test.
