Shikonin Suppresses Human T Lymphocyte Activation through Inhibition of IKKβ Activity and JNK Phosphorylation
Figure 3
Effect of shikonin on the cell cycle of human T lymphocytes stimulated by PMA/ionomycin. Human T cells (106) were pretreated with shikonin for 2 h then cultured with or without PMA (20 ng/mL)/ionomycin (1 μM) (P/I) for 72 h. The cell populations were measured by flow cytometry, and total percentages of the cells entering the S and G2/M phases of the cell cycle were indicated. Data are a representative experiment out of three independent experiments with similar results.
