Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice

Figure 4

A schematic plot for IDPN-induced tics in DA neurons of the striatum. The number of active DAT decreases triggered by IDPN, which leads to a mass of DA staying in the synaptic cleft. A higher concentration of DA may prolong the time span of DA-DR interconnection, facilitate excessive excitatory signals which may initiate abnormal motors such as tics.