Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 2

Research Article

The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors

Figure 2

AS-M induced apoptosis through the activation of multiple pathways. DBTRG-05MG cells were treated with AS-M (50 μg/mL) for 48 hours. Apoptosis markers were detected and analyzed by ICC using specific antibodies against (a) p16 and p53 for detection of the cell cycle pathway and (b)-(c) Bax, Bcl-2, cytochrome c, AIF, caspase-9, and caspase-3 for detection of the mitochondria-related apoptosis pathway.

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