The Herbal Drug Melampyrum pratense L. (Koch): Isolation and Identification of Its Bioactive Compounds Targeting Mediators
of Inflammation
Figure 6
Influence of Melampyrum pratense extracts (Mela MeOH: methanolic extract; Mela det: detannified methanol extract), subfractions (Mela OC 30/OC 70: 30%/70% methanolic SPE subfraction of the chlorophyll-depleted dichloromethane extract) and the respective compounds thereof on NF-κB activation. Extracts and fractions were tested at a concentration of 30 µg/mL, compounds at 30 μM with TNF-α cotreatment, in quadruplicate in three independent experiments. Parthenolide (10 μM) was used as positive control. Bars represent mean values, error bars consider standard error, and stars indicate significance compared to TNF-α induction (ANOVA/Bonferroni): ***.
