Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening

Figure 10

Effect of curcumin on the mitochondrial permeability transition pore-openining from rats exposed to K₂Cr₂O₇. (a) Mitochondrial swelling, (b) mitochondrial membrane potential dissipation, and (c) mitochondrial Ca²⁺ retention. Tracings are representative of three different experiments. Carbonyl cyanide m-chlorophenylhydrazone (CCCP) was added in control and curcumin groups to induce loss of membrane potential and Ca²⁺ release. CUR: curcumin; CsA: cyclosporine A.

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