Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening
Representative histopathology in rats treated with curcumin, K2Cr2O7—or both. (a) Control animal that received only the vehicle show normal hepatic architecture. (b) Rat liver section after one day or two days (c) of K2Cr2O7 administration; there are injured hepatocytes with nuclear condensation (pyknosis) and cytoplasmic vacuolization (arrows), as well as regenerative binucleated hepatocytes. (d) In contrast, administration of curcumin alone did not produce histological damage. (e) Rat treated with curcumin after one day of K2Cr2O7 administration shows normal liver histology. (f) Liver section after two days of K2Cr2O7 administration in animal pretreated with curcumin exhibited mild cytoplasmic vacuolation without pyknosis and binucleated regenerative hepatocytes (all micrographs H/E, magnification 1000X). (g) Quantitative morphometry shows significant liver protection in groups pretreated with curcumin. Values are mean ± SEM, 3-4. versus control; versus K2Cr2O7 (24 h); versus K2Cr2O7 (48 h).
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