Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Communication through Inactivation of NF-<i>κ</i>B

<table>Schematic hypothetical diagram of growth inhibition of MCF-7 cells by apoptosis in relation to enhanced GJIC treated with <i>c</i>9,<i>t</i>11-CLA and <i>t</i>10,<i>c</i>12-CLA isomers. Oxidative stress induced by CLA isomers might depolarize the cell membrane and open gap junction channel by expressing Cx43. Open gap junction channels allow exchange of cell death signaling ions and molecules which accelerate cell death through apoptosis as discussed in this study.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 7

Figure 7: Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Communication through Inactivation of NF-<i>κ</i>B 

Figure 7 | Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Communication through Inactivation of NF-κB 