Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

Figure 1

HLXL attenuates arthritic inflammation and joint damage in Lewis rats. A group each (𝑛=4 per group) of Mtb-immunized Lewis rats was fed either Water (Vehicle; (a), (c), (e), (g)) or HLXL (2.3 g/kg; (b), (d), (f), (h)), beginning at the onset of AA and then continued through d 18 after Mtb injection. (a), (b) (frontal view) and (c), (d) (lateral view) depict representative radiographs of hind limbs on d 18. Representative micrographs of tartrate-resistant-acid-phosphatase- (TRAP-) stained ((e), (f)) and safranin O-stained ((g), (h)) sections of the hind paw joints of control and HLXL-treated rats are shown.

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