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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 429606, 10 pages
Research Article

Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

1Department of Microbiology and Immunology, University of Maryland School of Medicine, HSF-1, Suite 380, 685 West Baltimore Street, Baltimore, MD 21201, USA
2Mailman Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
3Center for Integrative Medicine, University of Maryland School of Medicine, East Hall, 520 West Lombard Street, Baltimore, MD 21201, USA

Received 20 December 2012; Revised 8 March 2013; Accepted 8 March 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Siddaraju M. Nanjundaiah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

HLXL-treatment leads to reduction in the severity of arthritis as tested in the rat adjuvant arthritis (AA) model of human rheumatoid arthritis. Experimental group of arthritic Lewis rats was treated with HLXL, whereas the control group of arthritic rats was treated with the vehicle (Water). The treatment was begun at the onset of AA and then continued daily through the peak phase of AA. The severity of arthritis was assessed by arthritic scores and histological examination (Supplementary Figure 1) as well as by bone histomorphometry (Supplementary Figure 2) of hind paws.

  1. Supplementary Figures