5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins

Figure 9

5,7-Dihydroxyflavone synergized with TRAIL in the treatment of hepatocarcinoma xenografts. HepG2 cells were implanted into athymic mice subcutaneously. When the average tumor volume reached about 150 mm³, mice (𝑁=9) were treated for 28 days with vehicle control, 5,7-dihydroxyflavone (30 mg/kg/d) by oral gavage, TRAIL (10 mg/kg/d) i.p., and 5,7-dihydroxyflavone (30 mg/kg/d) by oral gavage + TRAIL(10 mg/kg/d) i.p.. (a) and (d) on day 29, tumors were isolated and weighed. (b) the tumor growth was monitored twice a week. (c) animal weights were recorded during the 28-day treatment. The asterisk indicates a significant difference (^∗𝑃<0.05, ^∗∗𝑃<0.01) compared with control. Data are mean ± SD.

(a)

(b)

(c)

(d)