Proteomic Analysis of the Effect of Acupuncture on the Suppression of Kainic Acid-Induced Neuronal Destruction in Mouse Hippocampus
Figure 3
Protein profiles with differential expression. (a) Hippocampal tissue protein profiles obtained over different pI ranges. (b) Representation of identified differential protein spots (red) in 2-DE gel templates among the saline, KA and groups. (c) Differential expression profiles of 11 proteins. Arrowheads on cropped images of 2-DE gels represent protein spots that showed different changes among the saline, KA and groups. (d) Quantitative analyses of downregulated or upregulated proteins by kainic acid (KA) and acupuncture stimulation at HT8. The spot intensities were derived from Coomassie-stained 2-D gels. VCP: valosin containing protein; ULMAE-1, ubiquitin-like modifier-activating enzyme 1 isoform 1; ATPS: ATP synthase subunit d; HSP70: heat shock 70 kDa protein 4L; HSP4L: heat shock protein 4 like isoform CRA_c; CRMP-2: dihydropyrimidinase-related protein 2; PURA: transcriptional activator protein Pur-alpha; PDX: pyruvate dehydrogenase protein X component; PP5: serine/threonine-protein phosphatase 5; TCP-1α: T-complex protein 1 subunit alpha; LOC433182: uncharacterized protein LOC433182. Data are expressed as the . * and ** versus the saline group. # versus the KA group.
