An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin

Figure 4

Target network and functional enrichment of the four herbs from QLY. A target network of each herb was uniquely identified by mapping the possible targets of each herb into RA-specific molecular network. The functions for the target networks were obtained by the functional enrichment tool (DAVID). These enriched biological functions are associated with RA. Targeting PTGS1 may lead to some adverse effects. Genes labeled in red color denote RA genes collected from OMIM, genes labeled in purple color denote the targets of the FDA-approved drugs for treating RA, and genes labeled in blue color represent RA genes predicted by CIPHER.