Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 469765, 7 pages
http://dx.doi.org/10.1155/2013/469765
Research Article

Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress

1School of Acupuncture-Moxibustion and Tui Na, Beijing University of Chinese Medicine, Beijing 100029, China
2Graduate School of China Academy of Chinese Medical Sciences, Beijing 100700, China
3Beijing Heping Hospital of Chaoyang District, Beijing 100103, China
4Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China

Received 28 March 2013; Revised 21 May 2013; Accepted 29 May 2013

Academic Editor: Gerhard Litscher

Copyright © 2013 Jun Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [32 citations]

The following is the list of published articles that have cited the current article.

  • Guangli Yan, Aihua Zhang, Hui Sun, Weiping Cheng, Xiangcai Meng, Li Liu, Yingzhi Zhang, Ning Xie, and Xijun Wang, “Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Yea-Hyun Leem, Sang-Sun Yoon, Yu-Han Kim, and Sangmee Ahn Jo, “Disrupted MEK/ERK signaling in the medial orbital cortex and dorsal endopiriform nuclei of the prefrontal cortex in a chronic restraint stress mouse model of depression,” Neuroscience Letters, 2014. View at Publisher · View at Google Scholar
  • Bo Wei, Yu-Pei Zhang, Hai-Zhen Yan, Yi Xu, and Tian-Min Du, “Cilostazol promotes production of melanin by activating the microphthalmia-associated transcription factor (MITF),” Biochemical and Biophysical Research Communications, vol. 443, no. 2, pp. 617–621, 2014. View at Publisher · View at Google Scholar
  • Yuping Mo, Haijiang Yao, Hongtao Song, Xin Wang, Wanshun Chen, Jiawula Abulizi, Anping Xu, Yinshan Tang, Xiangbo Han, and Zhigang Li, “Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Tianwei Guo, Zhuo Guo, Xinjing Yang, Lan Sun, Sihan Wang, A. Yingge, Xiaotian He, and Tu Ya, “The Alterations of IL-1Beta, IL-6, and TGF-Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after Electroacupuncture (EA) Pretreatment,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  • Gisela Borges, Esther Berrocoso, Juan Antonio Mico, and Fani Neto, “ERK1/2: Function, signaling and implication in pain and pain-related anxio-depressive disorders,” Progress In Neuro-Psychopharmacology & Biological Psychiatry, vol. 60, pp. 77–92, 2015. View at Publisher · View at Google Scholar
  • Rania I. Nadeem, Hebatalla I. Ahmed, and Ezz-El-Din S. El-Denshary, “Effect of Imipramine, Paroxetine, and Lithium Carbonate on Neurobehavioral Changes of Streptozotocin in Rats: Impact on Glycogen Synthase Kinase-3 and Blood Glucose Level,” Neurochemical Research, 2015. View at Publisher · View at Google Scholar
  • Peng Gao, Xi Gao, Tairan Fu, Dan Xu, and Qingping Wen, “Acupuncture: Emerging evidence for its use as an analgesic,” Experimental And Therapeutic Medicine, vol. 9, no. 5, pp. 1577–1581, 2015. View at Publisher · View at Google Scholar
  • Jie Liu, Shu-Rung Shi, Jian-You Guo, Yong Liu, Jin-Li Shi, and Yue-Wei Lyu, “Anxiolytic effect of antianxiety compound prescription capsule on acute stress in rats and influence upon expression of ERK/CREB signaling pathway and BDNF in the brain of rats,” Chinese Pharmacological Bulletin, vol. 31, no. 11, pp. 1614–1619, 2015. View at Publisher · View at Google Scholar
  • Ya Tu, Tian-wei Guo, Yun-chu Wu, Xue-qin Yang, Lan Sun, Xin-jing Yang, Wen-yue Zhang, Yu Wang, Xu-hui Zhang, and Zhuo Guo, “Electroacupuncture pretreatment exhibits anti-depressive effects by regulating hippocampal proteomics in rats with chronic restraint stress,” Neural Regeneration Research, vol. 10, no. 8, pp. 1298, 2015. View at Publisher · View at Google Scholar
  • Julia Dias Villas-Boas, Daniel Penteado Martins Dias, Pablo Ignacio Trigo, Norma Aparecida dos Santos Almeida, Fernando Queiroz de Almeida, and Magda Alves de Medeiros, “Acupuncture Affects Autonomic and Endocrine but Not Behavioural Responses Induced by Startle in Horses,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Jun-ying Wang, Shu-ping Chen, Yong-hui Gao, Li-na Qiao, Jian-liang Zhang, and Jun-ling Liu, “Effect of Repeated Electroacupuncture Intervention on Hippocampal ERK and p38MAPK Signaling in Neuropathic Pain Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Jian Xu, Yanling She, Ning Su, Ruixin Zhang, Lixing Lao, and Shifen Xu, “Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERK/ERK and p-P38/P38,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Muthmainah, and Ida Nurwati, “Acupuncture for Depression: The Mechanism Underlying Its Therapeutic Effect,” Medical Acupuncture, 2016. View at Publisher · View at Google Scholar
  • Yu Wang, Xuhui Zhang, Yingzhou Song, Tuya Bao, Miao Yu, Mingmin Xu, Yu Guo, Chuntao Zhang, and Bingcong Zhao, “Antidepressant-like effects of acupuncture involved the ERK signaling pathway in rats,” BMC Complementary and Alternative Medicine, vol. 16, no. 1, 2016. View at Publisher · View at Google Scholar
  • Dongmei Duan, Xianzhe Dong, Ya Tu, and Ping Liu, “A Microarray Study of Chronic Unpredictable Mild Stress Rat Blood serum with Electro-acupuncture Intervention,” Neuroscience Letters, 2016. View at Publisher · View at Google Scholar
  • Wenda Xue, Wei Wang, Tong Gong, Hailou Zhang, Weiwei Tao, Lihong Xue, Yan Sun, Fushun Wang, and Gang Chen, “PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine,” Scientific Reports, vol. 6, 2016. View at Publisher · View at Google Scholar
  • Jun Lu, Run-Hui Shao, Li Hu, Ya Tu, and Jian-You Guo, “Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats,” Neuroscience Letters, vol. 618, pp. 31–38, 2016. View at Publisher · View at Google Scholar
  • Dong-Mei Duan, Ya Tu, Ping Liu, and Shuang Jiao, “Antidepressant effect of electroacupuncture regulates signal targeting in the brain and increases brainderived neurotrophic factor levels,” Neural Regeneration Research, vol. 11, no. 10, pp. 1595–1602, 2016. View at Publisher · View at Google Scholar
  • Jun Shen, Junjian Zhang, Min Deng, Yue Liu, Yuan Hu, and Lei Zhang, “ The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats ,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–8, 2016. View at Publisher · View at Google Scholar
  • Yu Wang, Huili Jiang, Hong Meng, Jun Lu, Jing Li, Xuhui Zhang, Xinjing Yang, Bingcong Zhao, Yang Sun, and Tuya Bao, “Genome-wide transcriptome analysis of hippocampus in rats indicated that TLR/NLR signaling pathway was involved in the pathogenisis of depressive disorder induced by chronic restraint stress,” Brain Research Bulletin, 2017. View at Publisher · View at Google Scholar
  • Ren-zhong Kou, Hong Chen, Mei-ling Yu, Tian-cheng Xu, Shu-ping Fu, and Sheng-feng Lu, “Acupuncture for behavioral changes of experimental depressive disorder: a systematic review and meta-analysis,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Weidong Li, Yan Zhu, Shakir M. Saud, Qiujun Guo, Shengyan Xi, Baohui Jia, Shuang Jiao, Xiuyan Yang, Jun Lu, Sihong Song, and Ya Tu, “Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway,” Neuroscience Letters, vol. 642, pp. 43–50, 2017. View at Publisher · View at Google Scholar
  • Ling-Yong Xiao, Xue-Rui Wang, Ye Yang, Jing-Wen Yang, Yan Cao, Si-Ming Ma, Tian-Ran Li, and Cun-Zhi Liu, “Applications of Acupuncture Therapy in Modulating Plasticity of Central Nervous System,” Neuromodulation: Technology at the Neural Interface, 2017. View at Publisher · View at Google Scholar
  • Shi-Meng Zhou, Hong Wu, Lu Wang, Xiang Li, Qi Yang, Shao-Yu Guan, Le Yang, Liu-Kun Yang, Hui-Fang Nie, and Ming-Gao Zhao, “Cucurbitacin IIa exerts antidepressant-like effects on mice exposed to chronic unpredictable mild stress,” NeuroReport, vol. 28, no. 5, pp. 259–267, 2017. View at Publisher · View at Google Scholar
  • Yu Wang, Huili Jiang, Hong Meng, Jing Li, XinJing Yang, Bingcong Zhao, Yang Sun, and Tuya Bao, “Antidepressant Mechanism Research of Acupuncture: Insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–13, 2017. View at Publisher · View at Google Scholar
  • Xinjing Yang, Zhuo Guo, Jun Lu, Bingcong Zhao, Yutong Fei, Jing Li, Huili Jiang, Lan Sun, Yu Wang, Yang Sun, and Tuya Bao, “The Role of MAPK and Dopaminergic Synapse Signaling Pathways in Antidepressant Effect of Electroacupuncture Pretreatment in Chronic Restraint Stress Rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, pp. 1–9, 2017. View at Publisher · View at Google Scholar
  • Huili Jiang, Xuhui Zhang, Yu Wang, Huimin Zhang, Jing Li, Xinjing Yang, Bingcong Zhao, Chuntao Zhang, Miao Yu, Mingmin Xu, Qiuyun Yu, Xingchen Liang, Xiang Li, Peng Shi, and Tuya Bao, “Mechanisms Underlying the Antidepressant Response of Acupuncture via PKA/CREB Signaling Pathway,” Neural Plasticity, vol. 2017, pp. 1–11, 2017. View at Publisher · View at Google Scholar
  • Su Yeon Seo, Ji-Young Moon, Suk-Yun Kang, O. Sang Kwon, Sunoh Kwon, Se kyun Bang, Soo Phil Kim, Kwang-Ho Choi, and Yeonhee Ryu, “An estradiol-independent BDNF-NPY cascade is involved in the antidepressant effect of mechanical acupuncture instruments in ovariectomized rats,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Huili Jiang, Xuhui Zhang, Jun Lu, Hong Meng, Yang Sun, Xinjing Yang, Bingcong Zhao, and Tuya Bao, “Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor,” Frontiers in Psychiatry, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Jing Wang, Yuwei Jia, Guodong Li, Biao Wang, Ting Zhou, Li Zhu, Teng Chen, and Yanjiong Chen, “The Dopamine Receptor D3 Regulates Lipopolysaccharide-Induced Depressive-Like Behavior in Mice,” International Journal of Neuropsychopharmacology, 2018. View at Publisher · View at Google Scholar
  • Carolina Elisabetta Martins Maccariello, Carla Caroline Franzini de Souza, Laura Morena, Daniel Penteado Martins Dias, and Magda Alves de Medeiros, “Effects of acupuncture on the heart rate variability, cortisol levels and behavioural response induced by thunder sound in beagles,” Physiology & Behavior, 2018. View at Publisher · View at Google Scholar