Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function

Figure 2

Curcumin reduced infarct volume and improved neurological behavior in cerebral ischemia of rats. Rats were injected (i.p.) with curcumin and GW9662 for continuous 3 days. One hour after the last injections, the rats were subjected to MCAO for 2 h and reperfused for 24 h. (a) TTC staining of the brain. (b) Infarct volume of cerebral cortical and subcortical areas. Data were expressed as mean ± SD with 6 individual rats per group. (c) Determination of neurological deficits. Data were expressed as mean ± SD with 10 individual rats per group. **𝑃<0.01 versus sham-operated rats, ^##𝑃<0.01 versus MCAO rats, and ^Δ𝑃<0.05 versus curcumin-treated rats.

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