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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 472382, 8 pages
http://dx.doi.org/10.1155/2013/472382
Research Article

Effect of Semisolid Formulation of Persea Americana Mill (Avocado) Oil on Wound Healing in Rats

1Department of Pathology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
2Department of Physiology and Pharmacology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
3Department of Histology and Embryology, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
4Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil
5Department of Physiology and Pharmacology, Laboratory of Pharmacology of Bioactive Products, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil

Received 22 January 2013; Accepted 13 February 2013

Academic Editor: Gerhard Litscher

Copyright © 2013 Ana Paula de Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to evaluate the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natura, on incisional and excisional cutaneous wound models in Wistar rats. An additional objective was to quantify the fatty acids present in avocado oil. On the 14th day, a significant increase was observed in percentage wound contraction and reepithelialization in the groups treated with 50% SSFAO or avocado oil compared to the petroleum jelly control. Anti-inflammatory activity, increase in density of collagen, and tensile strength were observed inSSFAO 50% or avocado oil groups, when compared to control groups. The analysis of the components of avocado oil by gas chromatography detected the majority presence of oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%). Our results show that avocado oil is a rich source of oleic acid and contains essential fatty acids. When used in natura or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process and may thus be considered a new option for treating skin wounds.