The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy

Figure 7

The effects of NNAV on renal pathology in adriamycin-injected rats. Wistar rats were treated as described in the legend of Figure 1. At the end of the experiment, rats were killed and kidneys were dissected and fixed for hematoxylin and eosin ((a)–(e)), Masson’s trichrome ((f)–(j)), and periodic acid-Schiff ((k)–(o)) staining. Morphological analysis of renal pathology was performed with a light microscopy. It showed the glomerular deformation and damage (yellow arrows, (a)–(e)), tubular dilatation (green arrows, (a)–(e)), tubule interstitial collagen proliferation (yellow arrows, (f)–(j)), and glomerular basement membrane and mesangial expansion (yellow arrows, (k)–(o)) in the model group. NNAV reduced these pathological changes to a varying degree. Scale bar: 25 μm.