Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Fig 1

Research Article

Inhibitory Effects of Glycyrrhetinic Acid on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes and HERG Channel

Figure 1

Effect of GA on the of guinea pig ventricular myocytes. (a) Current traces elicited by 5 s test pulses from −10 to +80 mV with 10 mV increments, and tail currents recorded at −30 mV for 2 s. Representative traces of recorded from the same cell under control condition and after applying GA. Current-voltage relationship of (b) and (c) observed in five cells tested in the absence and presence of GA (1, 5, and 10 μM). Summary of the effects of GA (1, 5, and 10 μM) on (d) and (e), normalized relative to the control current ( , * , ** ).
481830.fig.001a
(a)
481830.fig.001b
(b)
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(c)
481830.fig.001d
(d)
481830.fig.001e
(e)

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