NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Effects of SAHA and BMX on primary hippocampal neuron viability by an MTT assay. SAHA and BMX (1, 2.5, 5, and 10 μM) were applied to primary hippocampal neurons at DIV 5 for 24 h. SAHA reduced the survival rate of hippocampal neurons at concentrations of 2.5, 5, and 10 μM. BMX showed little neurotoxic effect on the primary hippocampal neurons. The data are the mean ± SEM. **, in the comparison of the control group. **. One-way ANOVA followed by Newman-Keuls comparisons.