NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Effect of SAHA and BMX on Sco-induced memory impairment in water-maze memory acquisition and retrieval in rats. Control, scopolamine (Sco), (SAHA + Sco), and (BMX + Sco)-injected rats were subjected to water-maze training. The escape latency(s) of each water-maze learning trial ((a), upper) and the mean escape latency of each learning day ((a), lower) were recorded. On day 5, the hidden platform was removed, and the rats were allowed to swim for the probe trial test for 2 min. The time spent in each quadrant was recorded ((b), upper). The representative swimming pattern from the probe trial test is shown ((b), lower). We analyzed the swimming speed (c) and the escape latency of each water maze learning trial in the visible platform (d) to rule out any motor, visual, or motivation side effect of drugs. The data are the mean ± SEM. *, in the comparison of the control group; #, in the comparison between groups. ; . A two-way ANOVA followed by Newman-Keuls comparisons was applied for (a) and (b). A one-way ANOVA followed by Newman-Keuls comparisons was applied for (c) and (d).