The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity

Figure 4

Antiapoptotic effect of GE on Aβ-induced cytotoxicity in PC12 cells. (a) Representative plots for the flow cytometric analysis. (b) GE extract reduced Aβ-induced apoptosis in flow cytometric analysis. The fluorescence intensity was measured after PC12 cells were exposed to 20 μM Aβ for 48 h, followed by incubation with Annexin V-FITC and PI for 15 min. (c) 48 h treatment of GE extract attenuated Aβ-induced activation of caspase-3. Results are the means ± SD from three separate experiments. ^#𝑃<0.05 relative to control; *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 relative to Aβ treatment only by one-way ANOVA.

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