Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 518301, 12 pages
http://dx.doi.org/10.1155/2013/518301
Research Article

Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling

1Department of Biotechnology and Animal Science, College of Bioresources, National Ilan University, Ilan 260, Taiwan
2Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
3Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
4Department of Electrical Engineering, National Central University, Jhongli 32001, Taiwan
5Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan

Received 12 March 2013; Revised 7 June 2013; Accepted 9 June 2013

Academic Editor: Thomas Efferth

Copyright © 2013 Chao Yuan Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [14 citations]

The following is the list of published articles that have cited the current article.

  • Hui Gao, Qixiao Jiang, Yantao Han, Jianjun Peng, and Chunbo Wang, “Hispidulin Potentiates the Antitumor Effect of Sunitinib Against Human Renal Cell Carcinoma in Laboratory Models,” Cell Biochemistry and Biophysics, 2014. View at Publisher · View at Google Scholar
  • Edna Ribeiro-Varandas, Filipe Ressurreicao, Wanda Viegas, and Margarida Delgado, “Cytotoxicity of Eupatorium cannabinum L. ethanolic extract against colon cancer cells and interactions with Bisphenol A and Doxorubicin,” Bmc Complementary and Alternative Medicine, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Hui Gao, Jing Xie, Jianjun Peng, Yantao Han, Qixiao Jian, Mei Han, and Chunbo Wang, “Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder Cancer cells by targeting HIF-1α,” Experimental Cell Research, 2014. View at Publisher · View at Google Scholar
  • YanGang Wang, WeiPing Liu, XiaoSheng He, and Zhou Fei, “Hispidulin Enhances the Anti-Tumor Effects of Temozolomide in Glioblastoma by Activating AMPK,” Cell Biochemistry And Biophysics, vol. 71, no. 2, pp. 701–706, 2015. View at Publisher · View at Google Scholar
  • Klaokwan Srisook, Ekaruth Srisook, Wenuka Nachaiyo, Mingkwan Chan-In, Jitra Thongbai, Karnjanapa Wongyoo, Sasithorn Chawsuanthong, Kanita Wannasri, Sudarat Intasuwan, and Kingkan Watcharanawee, “Bioassay-guided isolation and mechanistic action of anti-inflammatory agents from Clerodendrum inerme leaves,” Journal of Ethnopharmacology, 2015. View at Publisher · View at Google Scholar
  • Fuqiang Li, Xiang Li, Yunjie Miao, Chenxiao Shan, Fei Yuan, Qiwen Wang, Chengyao Ma, Jianwei Chen, and Yong Chen, “UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin,” Journal of Pharmaceutical and Biomedical Analysis, vol. 125, pp. 310–318, 2016. View at Publisher · View at Google Scholar
  • Kanika Patel, and Dinesh Kumar Patel, “Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report,” Journal of Traditional and Complementary Medicine, 2016. View at Publisher · View at Google Scholar
  • Xue Ying, Zhao-Ping Li, Ya-Hua Wang, Hao-Lun Xu, Xia Li, and He-Lu Yan, “Preparation of Hispidulin Liposomes and Its Antitumor Effect in Vitro,” Chinese Pharmaceutical Journal, vol. 52, no. 18, pp. 1624–1628, 2017. View at Publisher · View at Google Scholar
  • Jian-Jun Peng, Yan-Tao Han, Hui Gao, Ming-Quan Gao, Mei Han, and Kai-Li Liu, “Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation,” Acta Pharmacologica Sinica, vol. 38, no. 12, pp. 1618–1631, 2017. View at Publisher · View at Google Scholar
  • Hongchuan Jin, Neelum Aziz Yousafzai, Hanying Wang, Mengjiao Han, Xian Wang, Dongjun Dai, Faliang Wang, Qiying Zhou, Haiqi Lu, Wenxia Xu, and Lifeng Feng, “CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer,” Oncotarget, vol. 8, no. 61, pp. 103557–103567, 2017. View at Publisher · View at Google Scholar
  • Keyong Ho Lee, Byeong- Soo Kim, and Ki-Hyeong Rhee, “Anti-tumor activity of Saussurea laniceps against pancreas adenocarcinoma,” Natural Product Sciences, vol. 23, no. 4, pp. 281–285, 2017. View at Publisher · View at Google Scholar
  • Mei Han, Hui Gao, Ping Ju, Ming-quan Gao, Yin-ping Yuan, Xue-hong Chen, Kai-li Liu, Yan-tao Han, and Zhi-wu Han, “Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ,” Biomedicine & Pharmacotherapy, vol. 103, pp. 272–283, 2018. View at Publisher · View at Google Scholar
  • Verena Lewenhofer, Lisa Schweighofer, Tobias Ledermüller, Julia Eichsteininger, Hanspeter Kählig, Martin Zehl, Chi H. Nguyen, Georg Krupitza, Ali Özmen, and Liselotte Krenn, “Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Mei Han, Hui Gao, Jing Xie, Yin-ping Yuan, Quan Yuan, Ming-quan Gao, Yan-tao Han, Zhi-wu Han, Kai-li Liu, and Xue-hong Chen, “Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway,” Acta Pharmacologica Sinica, 2018. View at Publisher · View at Google Scholar