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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 518301, 12 pages
http://dx.doi.org/10.1155/2013/518301
Research Article

Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling

1Department of Biotechnology and Animal Science, College of Bioresources, National Ilan University, Ilan 260, Taiwan
2Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
3Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
4Department of Electrical Engineering, National Central University, Jhongli 32001, Taiwan
5Division of General Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan

Received 12 March 2013; Revised 7 June 2013; Accepted 9 June 2013

Academic Editor: Thomas Efferth

Copyright © 2013 Chao Yuan Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. R. Kelley and J. M. Duggan, “Gastric cancer epidemiology and risk factors,” Journal of Clinical Epidemiology, vol. 56, no. 1, pp. 1–9, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-Y. Shin, J.-O. Kim, S. K. Lee, H.-S. Chae, and J.-H. Kang, “LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells,” BMC Cancer, vol. 10, article 425, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. R. Baeza, T. O. Giannini, S. R. Rivera et al., “Adjuvant radiochemotherapy in the treatment of completely resected, locally advanced gastric cancer,” International Journal of Radiation Oncology, Biology, Physics, vol. 50, no. 3, pp. 645–650, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Cascinu, M. Scartozzi, R. Labianca et al., “High curative resection rate with weekly cisplatin, 5-fluorouracil, epidoxorubicin, 6S-leucovorin, glutathione, and filgastrim in patients with locally advanced, unresectable gastric cancer: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD),” British Journal of Cancer, vol. 90, no. 8, pp. 1521–1525, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. D. B. Longley, D. P. Harkin, and P. G. Johnston, “5-fluorouracil: mechanisms of action and clinical strategies,” Nature Reviews Cancer, vol. 3, no. 5, pp. 330–338, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. C. J. Buskens, B. P. van Rees, A. Sivula et al., “Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus,” Gastroenterology, vol. 122, no. 7, pp. 1800–1807, 2002. View at Google Scholar · View at Scopus
  7. N. Kim, C. H. Kim, D.-W. Ahn et al., “Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling,” Journal of Gastroenterology and Hepatology, vol. 24, no. 3, pp. 480–487, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Kishimoto, K. Yashima, T. Morisawa, G. Shiota, H. Kawasaki, and J. Hasegawa, “Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane,” Journal of Gastroenterology, vol. 37, no. 3, pp. 186–193, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Y. Lim, H. J. Joo, J. H. Choi et al., “Increased expression of cyclooxygenase-2 protein in human gastric carcinoma,” Clinical Cancer Research, vol. 6, no. 2, pp. 519–525, 2000. View at Google Scholar · View at Scopus
  10. J. Houghton, J. G. Fox, and T. C. Wang, “Gastric cancer: laboratory bench to clinic,” Journal of Gastroenterology and Hepatology, vol. 17, no. 4, pp. 495–502, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. X. M. Fan, B. C. Y. Wong, M. C. M. Lin et al., “Interleukin-1β induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways,” Journal of Gastroenterology and Hepatology, vol. 16, no. 10, pp. 1098–1104, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. S. J. Baek, L. C. Wilson, and T. E. Eling, “Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53,” Carcinogenesis, vol. 23, no. 3, pp. 425–434, 2002. View at Google Scholar · View at Scopus
  13. F. G. Bottone Jr., S. J. Baek, J. B. Nixon, and T. E. Eling, “Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells,” Journal of Nutrition, vol. 132, no. 4, pp. 773–778, 2002. View at Google Scholar · View at Scopus
  14. L. C. Wilson, S. J. Baek, A. Call, and T. E. Eling, “Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of P53 in colorectal cancer cells,” International Journal of Cancer, vol. 105, no. 6, pp. 747–753, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. S. J. Baek, J.-S. Kim, F. R. Jackson, T. E. Eling, M. F. McEntee, and S.-H. Lee, “Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells,” Carcinogenesis, vol. 25, no. 12, pp. 2425–2432, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. J. B. Seung, J.-S. Kim, S. M. Moore, S.-H. Lee, J. Martinez, and T. E. Eling, “Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein,” Molecular Pharmacology, vol. 67, no. 2, pp. 356–364, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. T. E. Eling, S. J. Baek, M. Shim, and C. H. Lee, “NSAID activated gene (NAG-1), a modulator of tumorigenesis,” Journal of Biochemistry and Molecular Biology, vol. 39, no. 6, pp. 649–655, 2006. View at Google Scholar · View at Scopus
  18. T. Liu, A. R. Bauskin, J. Zaunders et al., “Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells,” Cancer Research, vol. 63, no. 16, pp. 5034–5040, 2003. View at Google Scholar · View at Scopus
  19. Y.-L. Chen, P.-C. Lin, S.-P. Chen et al., “Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 323, no. 2, pp. 746–756, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. T.-D. Way, J.-C. Lee, D.-H. Kuo et al., “Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 cells,” Journal of Agricultural and Food Chemistry, vol. 58, no. 6, pp. 3356–3365, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. L. K. Chao, P.-C. Liao, C.-L. Ho et al., “Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-κB pathway to reduce LPS-induced TNFa and no expression,” Journal of Agricultural and Food Chemistry, vol. 58, no. 6, pp. 3472–3478, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. C. Yang, H. Y. Lin, K. Y. Su et al., “Rutin, a flavonoid that is a main component of Saussurea involucrata, attenuates the senescence effect in D-galactose aging mouse model,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 980276, 10 pages, 2012. View at Publisher · View at Google Scholar
  23. M. Chulasiri, N. Bunyapraphatsara, and P. Moongkarndi, “Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L,” Environmental and Molecular Mutagenesis, vol. 20, no. 4, pp. 307–312, 1992. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Gil, M. J. Sanz, M. C. Ferrándiz et al., “Accelerated communication: effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice,” Life Sciences, vol. 54, no. 20, pp. PL333–PL338, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. R. X. Tan, H. Lu, J.-L. Wolfender et al., “Mono- and sesquiterpenes and antifungal constituents from Artemisia species,” Planta Medica, vol. 65, no. 1, pp. 64–67, 1999. View at Google Scholar · View at Scopus
  26. D. Kavvadias, V. Monschein, P. Sand, P. Riederer, and P. Schreier, “Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor,” Planta Medica, vol. 69, no. 2, pp. 113–117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Kavvadias, P. Sand, K. A. Youdim et al., “The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects,” British Journal of Pharmacology, vol. 142, no. 5, pp. 811–820, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. Y.-C. Lin, C.-M. Hung, J.-C. Tsai et al., “Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK),” Journal of Agricultural and Food Chemistry, vol. 58, no. 17, pp. 9511–9517, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Mickisch, S. Fajta, G. Keilhauer, E. Schlick, R. Tschada, and P. A lken, “Chemosensitivity testing of primary human renal cell carcinoma by a tetrazolium based microculture assay (MTT),” Urological Research, vol. 18, no. 2, pp. 131–136, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. M. van Engeland, L. J. Nieland, F. C. Ramaekers, B. Schutte, and C. P. Reutelingsperger, “Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure,” Cytometry, vol. 31, no. 1, pp. 1–9, 1998. View at Google Scholar
  31. L. F. Alfonso, K. S. Srivenugopal, T. V. Arumugam, T. J. Abbruscato, J. A. Weidanz, and G. J. Bhat, “Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells,” International Journal of Oncology, vol. 34, no. 3, pp. 597–608, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. F. V. Din, A. Valanciute, V. P. Houde et al., “Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells,” Gastroenterology, vol. 142, no. 7, pp. 1504–1515, 2012. View at Publisher · View at Google Scholar
  33. N. Wald, J. Morris, and M. Law, “Aspirin in the prevention of cancer,” The Lancet, vol. 377, no. 9778, p. 1649, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. A. V. Joshua, S. K. Sharma, A. Strelkov et al., “Synthesis and biodistribution of 8-iodo-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]-diazepine: Iozapine,” Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 14, pp. 4066–4069, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Yamaguchi, S.-H. Lee, T. E. Eling, and S. J. Baek, “A novel peroxisome proliferator-activated receptor γ ligand, MCC-555, induces apoptosis via post-transcriptional regulation of NAG-1 in colorectal cancer cells,” Molecular Cancer Therapeutics, vol. 5, no. 5, pp. 1352–1361, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S.-H. Lee, J.-S. Kim, K. Yamaguchi, T. E. Eling, and S. J. Baek, “Indole-3-carbinol and 3,3′-diindolylmethane induce expression of NAG-1 in a p53-independent manner,” Biochemical and Biophysical Research Communications, vol. 328, no. 1, pp. 63–69, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Newman, M. Sakaue, J. S. Koo et al., “Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids,” Molecular Pharmacology, vol. 63, no. 3, pp. 557–564, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. P. A. Baeuerle, “IκB-NF-κB structures: at the interface of inflammation control,” Cell, vol. 95, no. 6, pp. 729–731, 1998. View at Publisher · View at Google Scholar · View at Scopus
  39. P.-C. Liao, S.-C. Chien, C.-L. Ho et al., “Osthole regulates inflammatory mediator expression through modulating NF-KB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species,” Journal of Agricultural and Food Chemistry, vol. 58, no. 19, pp. 10445–10451, 2010. View at Publisher · View at Google Scholar · View at Scopus