The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease
Effects of PN-1 treatment (mg/kg once a day) on plaque pathology. (a) The percentage area occupied by plaques in the cortex and hippocampus. (b) The average number of plaques per square millimeter in the cortical primary sensory cortex (S1C), entorhinal cortex (EC), and motor cortex (MC) and hippocampal stratum oriens (Or), stratum radiatum (Ra), stratum lacunosum-moleculare (LM), molecular layer (Mo), and dentate gyrus (DG) hilus. (c) The mean fluorescence intensity of thioflavin-S positive staining plaques in the cortex and hippocampus (scale bar, 1 cm). Data represent means ± SEM ( mice/group) from 2 and 3 independent experiments. *, ** versus the vehicle-treated group.