Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1

Figure 1

Effects of Cur on the cytotoxicity of the primary cultured mesencephalic astrocytes. (a) Cell viability of the primary cultured mesencephalic astrocytes. (b) LDH release of the primary cultured mesencephalic astrocytes. (c) Morphologies of the primary cultured mesencephalic astrocytes. Primary cultured mesencephalic astrocytes were treated with the indicated concentrations of Cur (1, 3, 10, 30, and 50) (μM) for 48 h. The cell viability was determined with MTT. LDH release was measured by the LDH diagnostic kit. Morphological analysis was taken under bright field (magnification 40x). And data are presented as mean ± SD of three independent experiments, ^∗𝑃<0.05  and ^∗∗𝑃<0.01 compared to the control group.

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