Cartilage Protective and Chondrogenic Capacity of WIN-34B, a New Herbal Agent, in the Collagenase-Induced Osteoarthritis Rabbit Model and in Progenitor Cells from Subchondral Bone
Figure 1
Effects of WIN-34B on disease progression in the collagenase-induced arthritis rabbit model. Right knees of rabbits were intra-articularly injected with collagenase on days 1 and 4. 100 mg/kg, 200 mg/kg, and 400 mg/kg WIN-34B; 200 mg/kg CEL; 400 mg/kg ETCP or 1500 mg/kg Gluco-Hcl were orally administered for four weeks. (a) Stiffness (b) Hematoxylin-Eosin stained sections of knee joints from the normal, vehicle, WIN-34B 100 mg/kg, WIN-34B 200 mg/kg, WIN-34B 400 mg/kg, CEL 200 mg/kg, ETCP 400 mg/kg, and Gluco-Hcl 1500 mg/kg. (c) Cartilage area and (d) histopathologic scores evaluated at the tibial plateau and femur condyle in animals with collagenase-induced arthritis. Values are the mean ± SEM. # and ### compared to the normal group, *, **, and *** compared to the vehicle group. Two independent experiments were performed with similar results.
