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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 542081, 6 pages
Research Article

The Neuroprotective Effect of Gugijihwang-Tang on Trimethyltin-Induced Memory Dysfunction in the Rat

1Department of Basic Korean Medical Science, Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 130-701, Republic of Korea
2Hospital of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea
3Department of Basic Oriental Medical Science, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea

Received 21 November 2012; Revised 8 April 2013; Accepted 15 May 2013

Academic Editor: Rong Zeng

Copyright © 2013 Eun-Yee Jung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gugijihwang-Tang (the herbal formula PM012), a decoction consisting of several herbs including Rehmanniae Radix Preparata, has been widely used as herbal treatment for dementia. In order to investigate the neuroprotective action of this prescription, we examined the effect of Gugijihwang-Tang on learning and memory using the Morris water maze and [F-18]FDG micro PET neuroimaging technique. After injection of trimethyltin (TMT, 8.0 mg/kg, i.p.), which is a potent toxicant that selectively kills cells in the central nervous system, rats were administered Gugijihwang-Tang (100 mg/kg, p.o.) daily for two weeks, followed by the Morris water maze tasks and [F-18]FDG micro PET neuroimaging. In Gugijihwang-Tang administered TMT-treated rats, they showed improved learning and memory abilities in water maze tasks and glucose metabolism, suggesting that Gugijihwang-Tang plays effectively positive role in the improvement of brain function including learning and memory after TMT-induced neurodegeneration. Taken together, our results suggested that the Gugijihwang-Tang should be useful for developing strategies protecting nervous system and improving brain function.