Destruxin B Isolated from Entomopathogenic Fungus <i>Metarhizium anisopliae</i> Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in  Human Nonsmall Cell Lung Cancer Cells

<table>Isolation and purification of destruxin B from <i>Metarhizium anisopliae</i> fermentation broth. (a) Flowchart of the extraction and purification procedure. (b) HPLC chromatographic spectrum of purified destruxin B. <i>Metarhizium anisopliae</i> fermentation broth was centrifuged and filtered. The filtrate was extracted with CH<sub>2</sub>Cl<sub>2</sub>, and then the destruxin B was extracted and purified by ion-exchange chromatography, silica gel chromatography, and HPLC. (c) The chemical structure of destruxin B.</table>

Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: Destruxin B Isolated from Entomopathogenic Fungus <i>Metarhizium anisopliae</i> Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in  Human Nonsmall Cell Lung Cancer Cells 

Figure 1 | Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in  Human Nonsmall Cell Lung Cancer Cells 