Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 548929, 11 pages
http://dx.doi.org/10.1155/2013/548929
Research Article

Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells

1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
3Department of Health and Nutrition, Chia Nan University of Pharmacy & Science, Tainan, Taiwan
4Department of Applied Chemistry, Chaoyang University of Technology, Taichung, Taiwan
5Department of Applied Chemistry, National Chi Nan University, Puli, Nantou, Taiwan
6Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan

Received 20 March 2013; Accepted 20 August 2013

Academic Editor: Mei Tian

Copyright © 2013 Chun-Chi Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA: Cancer Journal for Clinicians, vol. 59, no. 4, pp. 225–249, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. R. Stratton, P. J. Campbell, and P. A. Futreal, “The cancer genome,” Nature, vol. 458, no. 7239, pp. 719–724, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. G. Kris, R. B. Natale, R. S. Herbst et al., “Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial,” Journal of the American Medical Association, vol. 290, no. 16, pp. 2149–2158, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Elmore, “Apoptosis: a review of programmed cell death,” Toxicologic Pathology, vol. 35, no. 4, pp. 495–516, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T. S. Mok, Y.-L. Wu, S. Thongprasert et al., “Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma,” The New England Journal of Medicine, vol. 361, no. 10, pp. 947–957, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. G. Cotter, “Apoptosis and cancer: the genesis of a research field,” Nature Reviews Cancer, vol. 9, no. 7, pp. 501–507, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Wang and R. J. Youle, “The role of mitochondria in apoptosis,” Annual Review of Genetics, vol. 43, pp. 95–118, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. T. J. Sayers, “Targeting the extrinsic apoptosis signaling pathway for cancer therapy,” Cancer Immunology, Immunotherapy, vol. 60, no. 8, pp. 1173–1180, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Katiyar, M. Yadav, and A. Tiwari, “Role of caspase in programmed cell death in multicellular organisms,” International Journal of Biomedical Research, vol. 2, no. 7, pp. 422–431, 2011. View at Google Scholar
  11. I. Budihardjo, H. Oliver, M. Lutter, X. Luo, and X. Wang, “Biochemical pathways of caspase activation during apoptosis,” Annual Review of Cell and Developmental Biology, vol. 15, no. 1, pp. 269–290, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Kroemer, “The proto-oncogene Bcl-2 and its role in regulating apoptosis,” Nature Medicine, vol. 3, no. 6, pp. 614–620, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Rong and C. W. Distelhorst, “Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis,” Annual Review of Physiology, vol. 70, pp. 73–91, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. R. J. Youle and A. Strasser, “The BCL-2 protein family: opposing activities that mediate cell death,” Nature Reviews Molecular Cell Biology, vol. 9, no. 1, pp. 47–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y.-L. P. Ow, D. R. Green, Z. Hao, and T. W. Mak, “Cytochrome c: functions beyond respiration,” Nature Reviews Molecular Cell Biology, vol. 9, no. 7, pp. 532–542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. J. W.-H. Li and J. C. Vederas, “Drug discovery and natural products: end of an era or an endless frontier?” Science, vol. 325, no. 5937, pp. 161–165, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. G. M. Cragg, P. G. Grothaus, and D. J. Newman, “Impact of natural products on developing new anti-cancer agents,” Chemical Reviews, vol. 109, no. 7, pp. 3012–3043, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Kopecký, V. Matha, and A. Jegorov, “The inhibitory effect of destruxin a on the replication of arboviruses in Aedes albopictus C6/36 cell line,” Comparative Biochemistry and Physiology C, vol. 103, no. 1, pp. 23–25, 1992. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Adachi, H. Nanba, and H. Kuroda, “Potentiation of host-mediated antitumor activity in mice by β-glucan obtained from Grifola frondosa (maitake),” Chemical and Pharmaceutical Bulletin, vol. 35, no. 1, pp. 262–270, 1987. View at Google Scholar · View at Scopus
  20. T. Ohmori, K. Tamura, S. Tsuru, and K. Nomoto, “Antitumor activity of protein-bound polysaccharide from Cordyceps ophioglossoides in mice,” Japanese Journal of Cancer Research, vol. 77, no. 12, pp. 1256–1263, 1986. View at Google Scholar · View at Scopus
  21. R. E. Moore, “Cyclic peptides and depsipeptides from cyanobacteria: a review,” Journal of Industrial Microbiology, vol. 16, no. 2, pp. 134–143, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. K. L. Rinehart, “Antitumor compounds from tunicates,” Medicinal Research Reviews, vol. 20, no. 1, pp. 1–27, 2000. View at Google Scholar
  23. G. A. Bradfisch and S. L. Harmer, “ω-conotoxin GVIA and nifedipine inhibit the depolarizing action of the fungal metabolite, destruxin B on muscle from the tobacco budworm (heliothis virescens),” Toxicon, vol. 28, no. 11, pp. 1249–1254, 1990. View at Publisher · View at Google Scholar · View at Scopus
  24. H.-C. Chen, C.-K. Chou, C.-M. Sun, and S. F. Yeh, “Suppressive effects of destruxin B on hepatitis B virus surface antigen gene expression in human hepatoma cells,” Antiviral Research, vol. 34, no. 3, pp. 137–144, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Odier, A. Vey, and J. P. Bureau, “In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E,” Biology of the Cell, vol. 74, no. 3, pp. 267–271, 1992. View at Google Scholar · View at Scopus
  26. J.-W. Chen, B.-L. Liu, and Y.-M. Tzeng, “Purification and quantification of destruxins A and B from Metarhizium anisopliae,” Journal of Chromatography A, vol. 830, no. 1, pp. 115–125, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. B. L. Liu, T. M. Rou, Y. K. Rao, and Y. M. Tzeng, “Effect of pH and aeration rate on the production of destruxins A and B from Metarhizium anisopliae,” International Journal of Applied Science and Engineering, vol. 5, no. 1, pp. 17–26, 2007. View at Google Scholar
  28. Y. P. Lee, C. W. Wang, W. C. Liao et al., “In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer,” Anticancer Research, vol. 32, no. 7, pp. 2735–2745, 2012. View at Google Scholar
  29. G.-C. Chang, C.-T. R. Yu, C.-H. Tsai et al., “An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells,” European Journal of Pharmacology, vol. 600, no. 1–3, pp. 37–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. B. S. Patil, G. K. Jayaprakasha, K. N. Chidambara Murthy, and A. Vikram, “Bioactive compounds: historical perspectives, opportunities and challenges,” Journal of Agricultural and Food Chemistry, vol. 57, no. 18, pp. 8142–8160, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Lemmens-Gruber, M. R. Kamyar, and R. Dornetshuber, “Cyclodepsipeptides—potential drugs and lead compounds in the drug development process,” Current Medicinal Chemistry, vol. 16, no. 9, pp. 1122–1137, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. E. Morel, M. Pais, M. Turpin, and M. Guyot, “Cytotoxicity of cyclodepsipeptides on murine lymphocytes and on L 1210 leukemia cells,” Biomedicine and Pharmacotherapy, vol. 37, no. 4, pp. 184–185, 1983. View at Google Scholar · View at Scopus
  33. C.-T. Yeh, Y. K. Rao, M. Ye et al., “Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging,” Toxicology and Applied Pharmacology, vol. 261, no. 1, pp. 31–41, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. R. M. Kluck, E. Bossy-Wetzel, D. R. Green, and D. D. Newmeyer, “The release of cytochrome c from mitochondria: a primary site for Bcl- 2 regulation of apoptosis,” Science, vol. 275, no. 5303, pp. 1132–1136, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Leber, J. Lin, and D. W. Andrews, “Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes,” Apoptosis, vol. 12, no. 5, pp. 897–911, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Cuconati, C. Mukherjee, D. Perez, and E. White, “DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells,” Genes and Development, vol. 17, no. 23, pp. 2922–2932, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Yu and L. Zhang, “PUMA, a potent killer with or without p53,” Oncogene, vol. 27, no. 1, pp. S71–S83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Chen, S. N. Willis, A. Wei et al., “Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function,” Molecular Cell, vol. 17, no. 3, pp. 393–403, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. M. S. Ola, M. Nawaz, and H. Ahsan, “Role of Bcl-2 family proteins and caspases in the regulation of apoptosis,” Molecular and Cellular Biochemistry, vol. 351, no. 1-2, pp. 41–58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. T.-J. Fan, L.-H. Han, R.-S. Cong, and J. Liang, “Caspase family proteases and apoptosis,” Acta Biochimica et Biophysica Sinica, vol. 37, no. 11, pp. 719–727, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Kumar, “Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?” Nature Reviews Cancer, vol. 9, no. 12, pp. 897–903, 2009. View at Publisher · View at Google Scholar · View at Scopus