Effects of Wenxin Keli on the Action Potential and L-Type Calcium Current in Rats with Transverse Aortic Constriction-Induced Heart Failure

Figure 4

Effects of WXKL on the 𝐼_Ca-L in the TAC group. (a) Representative 𝐼_Ca-L traces recorded from the control group. (b) Representative 𝐼_Ca-L traces recorded from the TAC group. (c) Representative 𝐼_Ca-L traces recorded from the TAC group in the presence of 5 g/L WXKL. (d) The peak current density-voltage relationship showed that the current densities in the TAC group were significantly increased by a range of −10 mV to +10 mV, and the current densities in the TAC group after treatment with 5 g/L WXKL were significantly reduced by a range of −10 mV to +40 mV. (e) The peak current densities in each group exhibited significant differences. ((f) and (g)) Representative 𝐼_Ca-L traces recorded from the control group and after treatment with 5 g/L WXKL. ^∗𝑃<0.05 and ^∗∗𝑃<0.01 versus the control group. ^Δ𝑃<0.05 and ^ΔΔ𝑃<0.01 versus the TAC group.