Matrine Inhibits Infiltration of the Inflammatory Monocyte Subset in Injured Mouse Liver through Inhibition of Monocyte Chemoattractant Protein-1
Figure 1
Mat protected mice against CCl4-induced acute liver injury and reduced hepatic inflammatory infiltration. (a) C57BL/6 mice were injected i.p. with CCl4 (0.6 mL/kg) diluted in corn oil, and sera were collected and analyzed for ALT levels at indicated time points. Data are expressed as the mean ± (SD) ( mice/group). versus corn oil control. (b) Liver tissues were collected at indicated time points after CCl4 injection, and liver sections were made and stained with hematoxylin-eosin (HE) (original magnification ×200). (c) Mat (10 mg/kg, 30 mg/kg) was administrated orally 3 h before CCl4 injection, and sera were collected and analyzed for ALT levels at 24 h after CCl4 injection. Data are expressed as the mean ± (SD) ( mice/group). versus normal group; versus CCl4-alone group. (d) Liver tissues were collected 24 h after CCl4 injection, and liver sections were made and stained with HE (original magnification ×200).
