Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice
Figure 2
Treatment with allantoin improves epididymal white adipose tissue (eWAT) in high fat diet-fed mice. The mice were fed a high fat diet (HFD) for 12 weeks. Then, allantoin (5 mg/kg) was intraperitoneally injected into the HFD-fed mice three times daily for 8 weeks. In another group, 1.5 mg/kg efaroxan was also injected into mice at 30 min before the injection of allantoin. At the end of the experiment, eWAT was isolated from each mouse. Histological evaluation of the eWAT was performed by staining with hematoxylin-eosin (magnification: 200).
